Absorption Kinetics of Ethanolamine Plasmalogen and Its Hydrolysate in Mice

Ethanolamine plasmalogen (PlsEtn), a subclass of ethanolamine glycerophospholipid (EtnGpl), has been reported to have many biological and dietary functions. In terms PlsEtn absorption, some studies that is re-esterized at the sn-2 position using lymph cannulation everted jejunal sac model. this study, we aimed better understand uptake kinetics increase its absorption. We thus compared with lyso-form, in which fatty acid was hydrolyzed enzymatically. Upon administration EtnGpl (extracted from oysters or ascidians, 75.4 mol% 88.4 ratio, respectively), plasma species mice showed highest levels 4 8 hours after administration. contrast, hydrolysate, contained lysoEtnGpl free acids, markedly increased 2 h The area under concentration-time curve (AUC), especially AUC0-4 species, higher hydrolysate than These results indicate hydrolysis accelerated absorption metabolism PlsEtn. Consequently, different experimental approach used previous studies, reconfirmed were absorbed via position, suggesting advance could uptake.